• ESET Smart Security Premium/Internet Security/NOD32 Antivirus 12: Microsoft Windows 10/8/7 SP1/Vista SP2/Home Server 2011 64-bit
  
• ESET Smart Security Premium/Internet Security/NOD32 Antivirus 11: Microsoft Windows 10/8/7/Vista/Home Server 2011
• ESET Smart Security Premium/Smart Security/Internet Security/NOD32 Antivirus 10: Microsoft Windows 10/8/7/Vista/Home Server 2011
• ESET Smart Security 9: Microsoft Windows 10/8/7/Vista/Home Server/XP SP3
• ESET NOD32 Antivirus 9: Microsoft Windows 10/8/7/Vista/Home Server/XP SP3
• ESET Smart Security 8: Microsoft Windows 10/8/7/Vista/Home Server/XP
• ESET NOD32 Antivirus 8: Microsoft Windows 10/8/7/Vista/Home Server/XP
• ESET Smart Security 7: Microsoft Windows 8/7/Vista/Home Server/XP
• ESET NOD32 Antivirus 7: Microsoft Windows 8/7/Vista/Home Server/XP
• ESET Cyber Security Pro 6.6 – 6.8: Catalina (macOS 10.15)/Mojave (macOS 10.14)/High Sierra (macOS 10.13)/Sierra (macOS 10.12)/El Capitan (OS X 10.11)/Yosemite (OS X 10.10)/Mavericks (OS X 10.9) with Intel Processor
• ESET Cyber Security 6.6 – 6.8: Catalina (macOS 10.15)/Mojave (macOS 10.14)/High Sierra (macOS 10.13)/Sierra (macOS 10.12)/El Capitan (OS X 10.11)/Yosemite (OS X 10.10)/Mavericks (OS X 10.9) with Intel Processor
• ESET Cyber Security Pro 6.x – 6.5: High Sierra (macOS 10.13)/Sierra (macOS 10.12)/El Capitan (OS X 10.11)/Yosemite (OS X 10.10)/Mavericks (OS X 10.9) with Intel Processor/Mountain Lion (OS X 10.8) with Intel Processor/Lion (OS X 10.7) with Intel Processor/Snow Leopard (OS X 10.6.x) with Intel Processor
• ESET Cyber Security 6.x – 6.5: High Sierra (macOS 10.13)/Sierra (macOS 10.12)/El Capitan (OS X 10.11)/Yosemite (OS X 10.10)/Mavericks (OS X 10.9) with Intel Processor/Mountain Lion (OS X 10.8) with Intel Processor/Lion (OS X 10.7) with Intel Processor/Snow Leopard (OS X 10.6.x) with Intel Processor
• ESET Cyber Security Pro 5.x: Mac OS X Mavericks (10.9) with Intel Processor/ Mountain Lion (10.8) with Intel Processor/Lion (10.7) with Intel Processor/Snow Leopard (10.6) with Intel Processor
• ESET Cyber Security 5.x: Mac OS X Mavericks (10.9) with Intel Processor/ Mountain Lion (10.8) with Intel Processor/Lion (10.7) with Intel Processor/Snow Leopard (10.6) with Intel Processor
• ESET Smart Security 6.0: Microsoft Windows 8*/7/Vista/Home Server/XP
• ESET NOD32 Antivirus 6.0: Microsoft Windows 8*/7/Vista/Home Server/XP
• ESET Cybersecurity for Mac (4.x): Mac OS X Mountain Lion (10.8) with Intel Processor/Lion (10.7) with Intel Processor/Snow Leopard (10.6) with Intel Processor/Leopard (10.5) with Intel Processor
• ESET Smart Security 5.2: Microsoft Windows 8*/7/Vista/Home Server/XP/2000
• ESET NOD32 Antivirus 5.2: Microsoft Windows 8*/7/Vista/Home Server/XP/2000/NT4
• ESET Smart Security 5.0: Microsoft Windows 7/Vista/Home Server/XP/2000
• ESET NOD32 Antivirus 5.0: Microsoft Windows 7/Vista/Home Server/XP/2000/NT4
• ESET Smart Security 4.2: Microsoft Windows 7/Vista/Home Server/XP/2000
• ESET NOD32 Antivirus 4.2: Microsoft Windows 7/Vista/Home Server/XP/2000/NT4
• ESET Smart Security 4.0: Microsoft Windows 7/Vista/Home Server/XP/2000
• ESET NOD32 Antivirus 4.0: Microsoft Windows 7/Vista/Home Server/XP/2000/NT4
• ESET Smart Security 3.0: Microsoft Windows Vista/XP/2000
• ESET NOD32 Antivirus 3.0: Microsoft Windows Vista/XP/2000
• ESET NOD32 Antivirus: Microsoft DOS
• ESET Mobile Security for Android version 3.x: Android 8 (Oreo)/Android 7 (Nougat)/Android 6 (Marshmallow)/Android 5 (Lollipop)/Android 4.4 (Kit Kat)/Android 4.1-4.3 (Jelly Bean)/Android 4.0 (Ice Cream Sandwich)
• ESET Mobile Security for Android version 1.1.1230: Android 2.0-4.1
• ESET Mobile Antivirus: Microsoft Windows Mobile 5.0, 6.0, 6.1, and 6.5

* ESET version 5.2 Windows home products are supported by Windows 8 but not certified as compatible by Microsoft.